Over a ten-year period, researchers in the Netherlands studied 26 adults with Loeys-Dietz syndrome type 3 (LDS-3) to determine how many of them experienced neurovascular abnormalities like aneurysms, arterial tortuosity (abnormal twisting of the arteries), arterial coiling, and arterial kinking and how these events impacted their health. 84.6% of individuals studied using neurovascular imaging showed some form of neurovascular abnormality, though only two individuals experienced significant issues during the study period.
Read MoreThis study examined aortic stiffness and aortic blood flow in the thoracic aorta of 21 adults with Loeys-Dietz syndrome (LDS) and compared their results to (1) adults with Marfan syndrome and (2) individuals with no known significant health issues.
Read MoreIn this article, the authors identify several key areas that require further research, including identifying new disease-causing variants not currently associated with TAA to build on what is already known about established TAA-associated mutations and using human, mouse, and stem cell models to study changes at the single-cell level for each stage of disease.
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